Fluorescent nanoprobes and nanostructures
Confinement of sensor materials into nanosized carriers is something that we use both as a technique to aid in other research and investigate its own right since it can be used to probe matter on the nanoscale, or to use the specifics of the length scale to provide for functions such as shielding of probes from electrophoretic effects, cell-penetrating or excluding properties, filtration capabilities or homogenous multisensing layers. In one work we described the facile production of novel highly fluorescent nanoparticles of polyvinylbutyral (PVB) and show their non-toxicity on human cell lines (Fig. 1) Current research is devoted on nanoporous glass for microbiosensors and combinations of fluorescent nanoparticles for microreactor imaging methods.
Publications in this area
(8) E. Poehler, C. Herzog, M. Suendermann, S.A. Pfeiffer, S. Nagl, Development of microscopic time domain dual lifetime referencing luminescence detection for pH monitoring in microfluidic free-flow isoelectric focusing, Eng. Life Sci. 2015, 15, 276-285
(7) J. Cao, S. Nagl, E. Kothe, J. M. Köhler, Application of oxygen sensor microparticles for monitoring bacterial growth and characterization of dose/response functions in microfluidic screenings, Microchim. Acta, 2015, 182, 385-394
(6) S. Jezierski, D. Belder, S. Nagl, Microfluidic free-flow electrophoresis chips with an integrated fluorescent sensor layer for real time pH imaging in isoelectric focusing, Chem. Commun. 2013, 49, 904-906
(5) D. Posavec, A. Dorsch, U. Bogner, G. Bernhardt, S. Nagl, Polyvinyl butyral nanobeads: Preparation, characterization, biocompatibility and cancer cell uptake, Microchim. Acta 2011, 173, 391-399
(4) S. Nagl, Fluorescent Multiple Chemical Sensing using Time-Domain Fluorescence Lifetime Imaging, Chapter 5, pp. 92 - 115, Doctoral Thesis, Universität Regensburg 2008
(3) A.S. Kocincová, S. Nagl, S. Arain, C. Krause, S.M. Borisov, M. Arnold, O.S. Wolfbeis, Multiplex bacterial growth monitoring in 24-well microplates using a dual optical sensor for dissolved oxygen and pH, Biotechnol. Bioeng. 2008, 100, 430-438
(2) M.I.J. Stich, S. Nagl, O.S. Wolfbeis, U. Henne, M. Schäferling, Dual Fluorescent Sensor Material for Simultaneous Imaging of Pressure and Temperature on Surfaces, Adv. Funct. Mater. 2008, 18, 1399-1406
(1) S.M. Borisov, T. Mayr, A. Karasyov, I. Klimant, P. Chojnacki, C. Moser, S. Nagl, M. Schäferling, M.I.J. Stich, G.S. Vasilevskaya, O.S. Wolfbeis, New Plastic Microparticles and Nanoparticles for Fluorescent Sensing and Encoding, Springer Series on Fluorescence 4 - Fluorescence of Supermolecules, Polymers and Nanosystems, Mário N. Berberan-Santos (ed.) Springer, Berlin, 2008
